HEPARINASE ENZYMES2019-09-23T15:33:47+00:00

Project Description

HEPARINASE ENZYMES

APPLICATION

Use for depolymerization of heparin, LMW heparin and heparan sulphate to component disaccharides.

USP monograph 207 – 1,6-Anhydro Derivative for Enoxaparin Sodium Ph. Eur. monograph 1097 – Enoxaparin sodium

DESCRIPTION

High quality Enzymes purified from Flavobacterium heparinum (ATCC 13125) for  depolymerization of heparin and LMW heparin including Enoxaparin Sodium.

Bacterial heparinases are eliminases that cleave the glycosidic linkage between amino sugars and uronic acids in heparin and when used in combination, heparinases bring about a near-complete depolymerisation of heparin to its constituent disaccharides.

At the site of cleavage these enzymes create a C4-C5 double bond in the uronic acid that absorbs at 232nm and can be used for the detection of degradation products.

Exceptionally pure and potent natural bacterial proteins; the specialist method of preparation gives baseline separation between the three heparinases producing very pure, world class enzymes.

SHIPPING, STORAGE AND EXPIRY

The enzymes are stabilised with 0.1-0.2% BSA (Sigma A4378), 0.22um-sterile filtered, dispensed into sterile vials and shipped on dry ice as frozen solutions.

The heparinase enzymes are stable for up to 24 months from the date of delivery when stored at -20°C or below in a solution of 0.1M Sodium Acetate pH 7.0 containing 1mM Calcium Acetate and 0.1% BSA.

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  • Heparinase I

    Catalogue # HEP-ENZ I
    Quantities available 0.5IU / 1.0IU / 2.0IU
    EC 4.2.27
    CAS Number 9025-39-2

    Degrades Heparin and Heparan Sulphate


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    Details
  • Heparinase II

    Catalogue # HEP-ENZ II
    Quantities available 0.5IU / 1.0IU / 2.0IU
    EC number not assigned
    CAS Number 14937112-0

    Degrades Heparin and Heparan Sulphate


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    Details
  • Heparinase III

    Catalogue # HEP-ENZ III
    Quantities available 0.5IU / 1.0IU / 2.0IU
    EC 4.2.2.8
    CAS Number 37290-86-1

    Degrades heparan sulfate


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    Details

HOW TO ORDER OR REQUEST A QUOTE

Fill in the form here, or email Iduron at info@iduron.co.uk.

Please send a list of the products you would like along with your delivery address and we will reply with a quote and lead time.

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